The Jeremy Kyle Show has been axed by ITV after the death of a guest who took part in the programme.
Steven Dymond was found dead on 9 May a week after filming the show, during which he took a lie detector test.
ITV's chief executive, Carolyn McCall, said the decision was a result of the "gravity of recent events".
The broadcaster had initially suspended filming, and the prime minister's spokesman called the death "deeply concerning".
ITV's statement in full:
"Given the gravity of recent events we have decided to end production of The Jeremy Kyle Show," McCall said.
"The Jeremy Kyle Show has had a loyal audience and has been made by a dedicated production team for 14 years, but now is the right time for the show to end.
"Everyone at ITV's thoughts and sympathies are with the family and friends of Steve Dymond."
The broadcaster added: "The previously announced review of the episode of the show is under way and will continue.
"ITV will continue to work with Jeremy Kyle on other projects."
The pre-recorded episode Mr Dymond took part in was based on the subject of infidelity.
A member of the audience who was at the recording told BBC News that Mr Dymond "collapsed to the ground" and was "sobbing" when he failed the lie detector test.
Lie detectors were a regular fixture on the programme, which often featured disputes between partners and family members.
Critics said it put vulnerable people, often with issues of addiction and mental health, on a public platform - bringing them a level of exposure they may not have expected.